Johne's Disease, Inflammatory Bowel Disease, and Mycobacterium paratuberculosis

Author:

Chacon Ofelia12,Bermudez Luiz E.3,Barletta Raúl G.1

Affiliation:

1. 1Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska 68583-0905;

2. 2Seccion de Bacteriología, Corporacion para Investigaciones Biologicas (CIB), Carrera 72A No. 78B 141, A.A. 7378, Medellín, Colombia

3. 3Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331;

Abstract

▪ Abstract  Johne's disease is a chronic diarrhea affecting all ruminants. Mycobacterium avium subsp. paratuberculosis (MAP), a slowly growing mycobacteria, is the etiologic agent. There is also a concern that MAP might be a causative agent of some cases of inflammatory bowel disease in humans, especially Crohn's disease. Food products including pasteurized bovine milk have been suggested as potential sources of human infection. This review addresses microbial factors that may contribute to its pathogenicity. In addition, the experimental evidence defining MAP as the cause of Johne's disease and the issues and controversies surrounding its potential pathogenic role in humans are discussed.

Publisher

Annual Reviews

Subject

Microbiology

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