Cell-Mediated Immunity and the Outcome of Hepatitis C Virus Infection-Reference-Cited by-同舟云学术

Cell-Mediated Immunity and the Outcome of Hepatitis C Virus Infection

Published:2004-10-01 Issue:1 Volume:58 Page:391-424
ISSN:0066-4227
Container-title:Annual Review of Microbiology
language:en
Short-container-title:Annu. Rev. Microbiol.

Author:

Shoukry Naglaa H.¹,Cawthon Andrew G.¹,Walker Christopher M.¹²

Affiliation:

1. 1Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, Ohio 43205, ,

2. 2College of Medicine and Public Health, Ohio State University, Columbus, Ohio 43205;

Abstract

▪ Abstract The hepatitis C virus (HCV) infects approximately three percent of the world's population. Some individuals resolve the infection spontaneously, but the majority develop persistent viremia that often causes progressive liver disease. There is an emerging consensus that cellular immune responses are essential for spontaneous resolution of acute hepatitis C and long-term protection from persistent infection. This review focuses on the recent advances in understanding mechanisms of protective immunity and why they fail in most infected individuals. The distinct yet complementary role of CD4+ and CD8+ T lymphocytes in this process is highlighted.

Publisher

Annual Reviews

Subject

Microbiology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.micro.58.030603.123836

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