A Putative Role of Hypercholesterolemia in Progressive Glomerular Injury-Reference-Cited by-同舟云学术

A Putative Role of Hypercholesterolemia in Progressive Glomerular Injury

Published:1992-02 Issue:1 Volume:43 Page:83-92
ISSN:0066-4219
Container-title:Annual Review of Medicine
language:en
Short-container-title:Annu. Rev. Med.

Author:

Diamond Jonathan R.¹,Karnovsky Morris J.²

Affiliation:

1. Division of Nephrology, The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033

2. Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Recently, much experimental evidence has accumulated contending that hypercholesterolemia is an aggravating factor in the progression of initial glomerular injury to glomerulosclerosis. Many of the features of progressive glomerular disease share biological properties with those of atherosclerosis, and data suggesting a noxious role for oxidized low-density lipoprotein in the glomerulosclerosis process are emerging. This review discusses these issues and examines the pathobiology of cholesterol-induced glomerular injury.

Publisher

Annual Reviews

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.me.43.020192.000503

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