Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat-Reference-Cited by-同舟云学术

Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat

Published:2021-07-28 Issue:12 Volume:90 Page:1594-1598
ISSN:0367-8318
Container-title:The Indian Journal of Animal Sciences
language:
Short-container-title:Indian J of Anim Sci

Author:

LONE ISFAQ BASIR,SINGH SATYA PAL,CHOUDHARY GOVIND KUMAR

Abstract

The present investigation was undertaken to evaluate immunomodulatory potential of Ajuga macrosperma against cyclophoshphamide (CP) induced immunosupression in rats. The immunological parameters such as haemaglutation (HA) titre and serum immunoglobulin (Ig) for humoral immunity (HI); lymphocyte stimulation test (LST), phagocytic index test, neutrophil adhesion test (NAT) and delayed type hypersensitivity reaction (DTH) for cellular immunity(CMI) were determined. The cyclophoshphamide treatment significantly suppressed both HI and CMI responses, which were significantly improved following treatment with 100 ppm and 200 ppm of methanolic extract of Ajuga macrosperma (MEAM) in dose dependent manner. The decreases in HI and CMI related parameters by CP treatment revealed immunosuppresion, whereas simultaneous treatment with MEAM ameliorated immune response which indicated immunomodulatory properties of Ajuga macrosperma.

Publisher

Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture

Subject

General Veterinary,Animal Science and Zoology

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