Author:
PROSKURA WITOLD STANIS£AW,DYBUS ANDRZEJ,ZABORSKI DANIEL,SOBEK ZBIGNIEW,YU YU-HSIANG,CHENG YEONG-HSIANG
Abstract
The sterol regulatory element-binding protein-1 (SREBP- 1) gene has been indicated to be linked to milk production traits in cattle, especially to milk fat yield and fatty acid composition. The transcription factor encoded by this gene is involved in the regulation of fat metabolism, so it is supposed that the variability of the SREBP-1 gene could influence these traits. The aim of this study was to analyze the association between the 84-bp insertion/deletion polymorphism of the SREBP-1 gene and milk production traits in Jersey cattle. The study found significant associations of the SREBP-1 gene polymorphism with fat content in the first lactation and protein content in the first three lactations analyzed both individually and together. In all cases, the LL genotype was linked to the higher value of the analyzed traits.
Publisher
Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
Subject
General Veterinary,Animal Science and Zoology
Reference19 articles.
1. Bennewitz J, Reinsch N, Guiard V, Fritz S, Thomsen H, Looft C, Kühn C, Schwerin M, Weimann C, Erhardt G, Reinhardt F, Reents R, Boichard D and Kalm E. 2004. Multiple quantitative trait loci mapping with cofactors and application of alternative variants of the false discovery rate in an enlarged granddaughter design. Genetics 168: 1019–27.
2. Bhuiyan M S A, Yu S L, Jeon J T, Yoon D, Cho Y M, Park E W, Kim N K, Kim K S and Lee J H. 2009. DNA polymorphisms in SREBF1 and FASN genes affect fatty acid composition in Korean Cattle (Hanwoo). Asian Australasian Journal of Animal Sciences 22: 765–73.
3. Boichard D, Grohs C, Bourgeois F, Cerqueira F, Faugeras R, Neau A, Rupp R, Amigues Y, Boscher M Y and Levéziel H. 2003. Detection of genes influencing economic traits in three French dairy cattle breeds. Genetic Selection Evolution 35: 77–101.
4. Brown M S and Goldstein J L. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a
5. membrane-bound transcription factor. Cell 89: 331–40.