Boswellia serrata normalizes altered haematological indices, attenuates pain and inflammation associated with adjuvant induced arthritis in rats

Abstract

A study was carried out to evaluate the anti-arthritic potential of Boswellia serrata on haematological parameters, pain and inflammation associated with adjuvant induced rheumatoid arthritis in rats. Thirty male Wistar rats were randomly divided in to 5 groups. While Group 1 served as normal control, Group 2 served as arthritic control, Groups 3, 4 and 5 served as treatment groups. Arthritis was induced in animals from Groups 2 to 5 with 0.1 ml of Freund's complete adjuvant injected intradermally into the foot pad of hindlimbs. Consequently, the onset of rheumatoid arthritis was indicated by hyperalgesia and inflammatory signs which were assessed by paw volume, paw diameter and paw withdrawal latency. Treatment protocol was followed from 3rd to 21st day, with Boswellia serrata given orally as methanolic extract at 500 mg/kg b.wt. to Group 3, meloxicam given subcutaneously at 1 mg/kg b.wt to Group 4 and both the drugs given concurrently to Group 5. The drug effects were evaluated on paw parameters and haematological indicators to depict the extent of paw inflammation and its subsequent amelioration. Conclusively, a major curative effect was witnessed with Boswellia serrata when compared to meloxicam.