Author:
KUMAR VIJAY,CHAKRAVARTY A K
Abstract
Genetic diseases have always been present in the animal population but their significance has increased in recent decades. In some breeds, the occurrence of inherited anomalies has become frequent and economically important. Some of autosomal recessive disorders are Holstein specific. The present review article describes prevalence of the most important autosomal recessive disorders in Holstein and its crossbreds as compared to their occurrence worldwide. Mainly five disorders namely, bovine leukocyte adhesion deficiency (BLAD), deficiency of uridine monophosphate synthase (DUMPS), bovine citrullinaemia, complex vertebral malformation (CVM) and factor XI (FXI) deficiency syndrome, are being screened in Indian Holstein and its crossbred cattle with the major objective to reduce the incidence of genetic disorders in cattle population and reduce the economic losses to the organized farms. Detection of heterozygote carriers enables their selection, and therefore, the control and prevention of the spread of recessive diseases in the population.
Publisher
Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
Subject
General Veterinary,Animal Science and Zoology
Reference28 articles.
1. Adamov N, Mitrov D, Esmerov I and Dovc P. 2014. Detection of recessive mutations (BLAD and CVM) in Holstein-Friesian cattle population in Republic of Macedonia. Macedonian Veterinary Review 37 (1): 61–68.
2. Agerholm J S, Andersen O, Almskou M B, Bendixen C, Arnbjerg J, Aamand G, Nielsen U S, Panitz F and Petersen A H. 2004. Evaluation of the inheritance of complex vertebral malformation syndrome by breeding studies. Acta Veterinaria Scandinavica 45 (3): 133–37.
3. Agerholm J S, Bendixen C, Andersen O and Ambjerg J. 2001. Complex vertebral malformation in Holstein calves. Journal of Veterinary Diagnostic Investigation 13: 283–89.
4. Akyuz B, Ertugrul O and Agaoglu O K. 2010. Detection of bovine leukocyte adhesion deficiency (BLAD) allele in Holstein cows reared in Kayseri Vicinity. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 16 (2): 519–21.
5. Akyuz B and Ertugrul O. 2008. Detection of deficiency of uridine monophosphate synthase (DUMP) in Holstein and native cattle in Turkey. Veterinary Journal of Ankara University 55: 57– 60.