Tools to Rapidly Produce and Screen Biodegradable Polymer and Sol-Gel-Derived Xerogel Formulations

Author:

Cho Eun Jeong1,Tao Zunyu1,Tang Ying1,Tehan Elizabeth C.1,Bright Frank V.1,Hicks Wesley L.1,Gardella Joseph A.1,Hard Robert1

Affiliation:

1. Department of Chemistry, Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000 (E.J.C., Z.T., Y.T., E.C.T., F.V.B., J.A.G.); Department of Head and Neck Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263 (W.L.H.); and Department of Anatomy and Cell Biology, Farber Hall, University at Buffalo, The State University of New York, Buffalo, New York 14214 (R.H.)

Abstract

A new method to rapidly produce and screen biodegradable polymer- and xerogel-based formulations is described. The approach is based on a high-speed pin printer and imaging with an epi-fluorescence microscope/charge-coupled device detector. By using this approach we can produce and screen over 600 formulations/h and rapidly identify lead formulations and/or compositions that are the most useful for the development of biodegradable devices or (bio)sensors.

Publisher

SAGE Publications

Subject

Spectroscopy,Instrumentation

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