Infrared Spectroscopy of Human Cells and Tissue. Part VI: A Comparative Study of Histopathology and Infrared Microspectroscopy of Normal, Cirrhotic, and Cancerous Liver Tissue

Author:

Chiriboga Luis1,Yee Herman1,Diem Max1

Affiliation:

1. Department of Pathology, Bellevue Hospital and New York University Medical Center, 27th Street and First Avenue, New York, New York 10016 (L.C., H.Y.); and Department of Chemistry and Biochemistry, City University of New York, Hunter College, 695 Park Avenue, New York, New York 10021 (L.C., M.D.)

Abstract

Infrared spectra of selected regions of normal, cirrhotic, and neoplastic liver tissue samples are reported. Spectra of these tissues may vary for a number of reasons that may or may not be related to the state of health or disease. With the use of histochemical and immunohistochemical methods, the spectral variations are interpreted in terms of the biochemical and pathological processes involved. This paper lays the groundwork for correlation of infrared spectroscopic and pathological/histochemical results for other tissues, to be reported in subsequent communications.

Publisher

SAGE Publications

Subject

Spectroscopy,Instrumentation

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