Phase-Resolved Fiber-Optics Fluoroimmunosensor-Reference-Cited by-同舟云学术

Phase-Resolved Fiber-Optics Fluoroimmunosensor

Published:1990-01 Issue:1 Volume:44 Page:128-132
ISSN:0003-7028
Container-title:Applied Spectroscopy
language:en
Short-container-title:Appl Spectrosc

Author:

Vo-Dinh T.¹,Nolan T.¹,Cheng Y. F.¹,Sepaniak M. J.¹,Alarie J. P.¹

Affiliation:

1. Advanced Monitoring Development Group, Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6101 (T.V.-D., T.N., Y.F.C.); and Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37916 (M.J.S., J.P.A.)

Abstract

This paper describes the development and application of a phase-resolved fiber-optics fluoroimmunosensor (PR-FIS), which combines the biochemical specificity of antigen-antibody reaction, the high sensitivity of laser excitation, the versatility of fiber-optics sensors, and the selectivity of phase-resolved detection. The PR-FIS device can differentiate benzo(a)pyrene and benzo(a)pyrene tetrol, a DNA-adduct product of the carcinogen benzo(a)pyrene. Benzo(a)pyrene tetrol can be detected at femtomole levels in the presence of an amount of interfacing benzo(a)pyrene that is 50-fold more concentrated.

Publisher

SAGE Publications

Subject

Spectroscopy,Instrumentation

Link

http://journals.sagepub.com/doi/pdf/10.1366/0003702904085859

Reference12 articles.

1. Fiber-Optic Sensors for Biomedical Applications

2. Chemical Sensors Based on Fiber Optics

3. A Portable Fiberoptic Monitor for Fluorimetric Bioassays

4. Fiber-optic chemical sensors for competitive binding fluoroimmunoassay

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