Research Strategy for the HPLC/FT-IR Analysis of Drug Metabolites-Reference-Cited by-同舟云学术

Research Strategy for the HPLC/FT-IR Analysis of Drug Metabolites

Published:1997-06 Issue:6 Volume:51 Page:866-873
ISSN:0003-7028
Container-title:Applied Spectroscopy
language:en
Short-container-title:Appl Spectrosc

Author:

Pivonka D. E.¹,Kirkland K. M.¹

Affiliation:

1. Zeneca Pharmaceuticals, A Business Unit of Zeneca Inc., 1800 Concord Pike, Wilmington, Delaware 19897

Abstract

A strategy for the infrared spectroscopic analysis of drug metabolites in high-pressure liquid chromatography (HPLC) effluent is presented with a primary focus on delivery of metabolite structure as opposed to development of dedicated or automated instrumentation. This paper stresses the complementary nature of on-line (solution phase) and off-line (condensed phase) HPLC Fourier transform infrared (FT-IR) implementations for structural elucidation of drug metabolites.

Publisher

SAGE Publications

Subject

Spectroscopy,Instrumentation

Link

http://journals.sagepub.com/doi/pdf/10.1366/0003702971941151

Reference14 articles.

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4. Microbore high-performance liquid chromatography/Fourier transform infrared interface for normal- or reverse-phase liquid chromatography

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