Antibacterial Activity of Vanillic Acid against Staphylococcus aureus, Salmonella typhi, and Proteus mirabilis

Abstract

Aim. This study investigated the efficacy of vanillic acid against selected pathogenic bacteria obtained from clinical samples. Method. The antibacterial efficacy of vanillic acid against selected pathogenic bacteria collected from clinical samples was studied using a broth macrodilution method. The minimum inhibitory concentration was determined by treating each isolate with increasing amounts of vanillic acid ranging from 150 to 2000 µg/ml. Results. The lowest inhibitory concentrations found were 600 µg/ml for Staphylococcus aureus, Proteus mirabilis, and Salmonella Typhi, and the time-kill susceptibility test also demonstrated a significant reduction in viable cells of the bacterial isolates investigated in this study. The findings of this study confirmed the antimicrobial effect of vanillic acid on bacterial growth and its activity against Staphylococcus aureus, Proteus mirabilis, and Salmonella Typhi. Conclusion. Vanillic acid may provide a solution for alternate therapeutic choices for diseases caused by Staphylococcus aureus, Proteus mirabilis, and Salmonella Typhi.