Membrane theory of the pathogenesis of arterial hypertension: What do we know about this, half a century later?

Author:

Orlov S. N.1

Affiliation:

1. Lomonosov Moscow State University; National Research Tomsk State University; Siberian State Medical University

Abstract

The review summarizes the history of the discovery in the mid-70s of the impaired ion transport across the plasma membrane of cells during primary arterial hypertension. A half-century’s history of studies on the molecular nature of the ionic transporters underlying these disorders and the mechanisms mediated by them leading to the development of hypertension and complications caused by a long-term increase in blood pressure is analyzed.

Publisher

Siberian State Medical University

Subject

Molecular Medicine

Reference112 articles.

1. Orlov S.N., Danilov V.S., Malkov A.Yu., Rebrov V.G. Free radical lipid oxidation of biological membranes. V(?). Fluorescence of fatty acids and phospholipids. Biophysics. 1975; 20 (2): 228–232].

2. Jones A.W. Altered ion transport in vascular smooth muscle from spontaneously hypertensive rats. Influence of Aldosterone, Norepinephrine and Angiotensin. 1973; 33:563–572.

3. Folkow B., Grimby G., Thulesius O. Adaptive structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance. Acta Physiol. Scand. 1958; 44 (3–4): 255–272.

4. Postnov Yu.V., Orlov S.N., Shevchenko A.S. Change in erythrocyte membrane permeability in rats with spontaneous hypertension. Cardiology. 1975; 15 (1): 88–92 (in Russ.)].

5. Postnov Yu.V., Orlov S.N., Gulak P.V., Shevchenko A.S. Altered permeability of the erythrocyte membrane for sodium and potassium in spontaneously hypertensive rats. Pflugers Archiv. 1976; 365 (2–3): 257–263.

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