Mitochondrial DNA as DAMP in critical conditions-Reference-Cited by-同舟云学术

Mitochondrial DNA as DAMP in critical conditions

Published:2019-10-27 Issue:3 Volume:18 Page:134-143
ISSN:1819-3684
Container-title:Bulletin of Siberian Medicine
language:
Short-container-title:Bûll. sib. med.

Author:

Grigoriev E. V.¹^ORCID,Salakhov R. R.²^ORCID,Golubenko M. V.³^ORCID,Ponasenko A. V.⁴^ORCID,Shukevich D. L.¹^ORCID,Matveeva V. G.⁴^ORCID,Radivilko A. S.⁴^ORCID,Tsepokina A. V.⁴^ORCID,Velikanova E. A.⁴^ORCID,Kornelyuk R. S.¹^ORCID,Ivkin A. S.¹^ORCID

Affiliation:

1. Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University (KSMU)

2. Research Institute of Medical Genetics, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences

3. Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; Research Institute of Medical Genetics, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences

4. Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases

Abstract

The focus of the researchers’ attention today includes the recently discovered role of mitochondria in the immune response. Increasing evidence shows that mitochondrial DNA, in retaining some of their characteristics of the ancient α-proteobacteria’s genome, is a potent immune stimulus for inflammatory reactions. Systemic inflammatory response is a frequent complication in surgical interventions and various traumas, and its development cannot be explained using common conceptions. This review provides information on the current understanding of the development of inflammation mediated by mtDNA, including systemic inflammatory response, and on the mechanisms regulating mitochondrial homeostasis and mtDNA release in various pathological conditions.

Publisher

Siberian State Medical University

Subject

Molecular Medicine

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