Benzobarbital and fluorbenzobarbital - hepatic monooxygenase system phenobarbital-like inducers-Reference-Cited by-同舟云学术

Benzobarbital and fluorbenzobarbital - hepatic monooxygenase system phenobarbital-like inducers

Published:2011-10-28 Issue:5 Volume:10 Page:78-81
ISSN:1819-3684
Container-title:Bulletin of Siberian Medicine
language:
Short-container-title:Bûll. sib. med.

Author:

Novozheyeva T. P.,Smagina M. I.,Cherevko N. A.,Fateyeva S. N.

Abstract

Benzobarbital and fluorbenzobarbital as monooxygenase system inductors increase the hepatic cytochrome P-450 level and the content of its isoenzymes 2B6, 2C9, 2Å1, accelerate aminopyrine, 7-ethoxyresorufine, 7-pentoxyresorufine, aniline and androstendione oxidation. Activity of benzobarbital and fluorbenzobarbital as inductors is to a large degree due to the action of their major metabolite — phenobarbital. Benzobarbital and fluorbenzobarbital unlike phenobarbital induce isoenzyme 3A4, responsible for androstendione 16b-OH-hydroxylation. PCN-type induction activity posses also native molecules of benzobarbital and fluorbenzobarbital.

Publisher

Siberian State Medical University

Subject

Molecular Medicine

Reference15 articles.

1. Archakov A.I., Lisitsa A.V., Petushkova N.A. i dr. Tsitokhromy R-450, lekarstvennaya bolezn' i personifitsirovannaya meditsina//Klinich. meditsina. 2008. T. 86, ¹ 2. S. 4-8.

2. Vengerovskii A.I. Pervaya kafedra farmakologii Sibiri//Eksperim. i klinich. farmakologiya. 2008. T. 71, ¹ 2. S. 60-64.

3. Kukes V., Sychev D., Shikh E. Izuchenie biotransformatsii lekarstvennykh sredstv -put' k povysheniyu effektivnosti i bezopasnosti farmakoterapii//Vrach. 2007. ¹ 1. S. 68-75.

4. Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh sredstv/pod red. R.U. Khabrieva M.: Meditsina, 2005. 832 s.

5. Saratikov A.S., Novozheeva T.P. Antikonvul'santy i monooksigenaznaya sistema//Zhurn. nevrologii i psikhiatrii im. S.S. Korsakova. 1991. T. 91, ¹ 6. S. 104-108.

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