Analysis of the combined effect of polymorphisms interferon genes OAS1, OAS3, PKR, IFNA17 and IFNG in susceptibility to chronic viral hepatitis C-Reference-Cited by-同舟云学术

Analysis of the combined effect of polymorphisms interferon genes OAS1, OAS3, PKR, IFNA17 and IFNG in susceptibility to chronic viral hepatitis C

Published:2011-06-28 Issue:3 Volume:10 Page:19-23
ISSN:1819-3684
Container-title:Bulletin of Siberian Medicine
language:
Short-container-title:Bûll. sib. med.

Author:

Bychkov V. A.,Ryazantseva N. V.,Novitsky V. V.

Abstract

Interferon system plays a key role in the antiviral response. Based on data from the literature, the most dangerous for the development of infectious diseases is the combination of risk alleles of several genes. This study focuses on the analysis of the combined effect of single nucleotide polymorphisms of interferon system genes OAS1, OAS3, PKR, IFNA17 and IFNG in the predisposition to chronic viral hepatitis C. It has been shown that the accounting of several risk genes improves the prediction of development of this disease.

Publisher

Siberian State Medical University

Subject

Molecular Medicine

Reference13 articles.

1. Baranov V.S., Baranova E.V., Ivashchenko T.E. Nauchnye osnovy prediktivnoi meditsiny//Molekulyarno-biologicheskie tekhnologii v meditsinskoi praktike: sb. nauch. trudov/pod red. A.B. Maslennikova. Vyp. 4. Novosibirsk: Al'fa Vista, 2003. 252 s.

2. Bychkov V.A., N.V. Ryazantseva, V.V. Novitskii i dr. Assotsiatsiya polimorfizmov genov sistemy interferona OAS1, OAS3, PKR i khronicheskogo virusnogo gepatita C//Med. immunologiya. 2011. T. 13, № 1. S. 93-100.

3. Lobzin Yu.V., Zhdanov K.V., Volzhanin V.M., Gusev D.A. Virusnyi gepatit: klinika, diagnostika, lechenie. SPb.: OOO «Foliant», 2003. 192 s.

4. Maniatis T. Metody geneticheskoi inzhenerii. M.: Mir, 1984. 480 s.

5. Puzyrev V.P. Genetika mul'tifaktorial'nykh zabolevanii: mezhdu proshlym i budushchim//Med. genetika. 2003. T. 2, № 12. S. 498-508.

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ideas and methods of nonlinear mathematics and theoretical physics in DNA science: the McLaughlin-Scott equation and its application to study the DNA open state dynamics;Biophysical Reviews;2021-05-13

2. Analytical Approaches to Investigating the Dynamics of Genes with a Single Coding Region;Biophysics;2018-01

3. Forced oscillations of DNA bases;Biophysics;2016-03

4. Rotational dynamics of bases in the gene coding interferon alpha 17 (IFNA17);Journal of Bioinformatics and Computational Biology;2015-02