Affiliation:
1. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Abstract
The review covers the current concepts on structural and functional heterogeneity of brain astrocytes that serve for numerous (patho)physiological processes in the central nervous system. Astrocytes from various subpopulations demonstrate different sensitivity to the action of pathogenic factors, varied behaviors in reactive processes and within the local immune response. Key functions of astrocytes like neurogenesis, neuron-astroglia metabolic coupling, glial control of local blood flow greatly depend on the origin and characteristics of astroglial cells. Changes at the initial stages of neurodegeneration or in neurodevelopmental disorders are associated with significant alterations in astroglial structural and functional properties, thus suggesting new approaches to therapeutic strategies implementing astroglia-expressing molecules and targets for effective
Publisher
Siberian State Medical University
Reference65 articles.
1. . Freeman M.R. Neuron-Glia Signaling in Nervous System Development, Function, and Disease. URL: http://www.hhmi. org/research/ecs/freeman.html (accessed 14 March 2013).
2. Shaham S. Glia–Neuron Interactions in Nervous System Function and Development. Curr. Top. Dev. Biol., 2005, vol. 69, pp. 39–66.
3. Mozhayeva G.N., Alekseenko V.A., Kaznacheeva E.V., Kiselev K.I., Mamin A.G., Semenova S.B. Ion channels providing receptor-induced Ca-influx through plasma membrane of nonexcitable cells. Informatsionny byulleten RFFI – Information. Bull. RFBR, 1996, vol. 4, no. 4, pp. 299 (in Russian).
4. Brough D., Le Feuvre R.A., Wheeler R.D., Solovyova N., Hilfiker S., Rothwell N.J., Verkhratsky A. Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. J. Immunol., 2003, vol. 170, no. 6, pp. 3029–3036.
5. Picello E., Pizzo P., Di Virgilio F. Chelation of cytoplas-mic Ca2+ increases plasma membrane permeability in murine macrophages. J. Biol. Chem., 1990, vol. 265, no. 10, pp. 5635–5639.
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