GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD-Reference-Cited by-同舟云学术

GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD

Published:2014-02-28 Issue:1 Volume:13 Page:47-55
ISSN:1819-3684
Container-title:Bulletin of Siberian Medicine
language:
Short-container-title:Bûll. sib. med.

Author:

Kulikov Ye. S.¹,Ogorodova L. M.¹,Freidin M. B.²,Saltikova I. V.¹,Deyev I. A.¹,Selivanova P. A.¹

Affiliation:

1. Siberian State Medical University, Tomsk

2. Research Institute of Medical Genetics, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk

Abstract

Introduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip. Cluster analysis was performed.Results and conclusion: According to our data several mechanisms of therapy resistance may be considered: increased levels of nitric oxide and beta2-agonists nitration, dysregulation of endogenous steroids secretion and involvement in the pathogenesis of Staphylococcus aureus. Absence of suppression of gene expression KEGG-pathway “asthma" may reflect the low efficiency or long period of anti-inflammatory therapy effect realization.

Publisher

Siberian State Medical University

Subject

Molecular Medicine

Reference26 articles.

1. Chung K.F., Godard P., Adelroth E. Difficult therapyresistant asthma. Eur. Respir. J., 1999, 13, pp. 1198–1208.

2. Fedoseyev G.B., Trofimov V.I., Petrova M.A. The many faces of asthma, diagnosis, treatment and prevention. Moscow, Nordmedizdat Publ., 2011. P. 343 (in Russian).

3. Global strategy for the treatment and prevention of bronchial asthma. Ed. A.S. Belevsky. Moscow, Russian Respiratory Society, 2012. 108 p. (in Russian).

4. Miller M.K., Johnson C., Miller D.P. et al. Severity assessment in asthma: an evolving concept. J. Allergy Clin. Immunol., 2005, 116, pp. 990–995.

5. Chuchalin A.G., Ogorodova L.M., Petrovsky F.I et al. Therapeutic archive, 2005, 77 (3), pp. 36–42 (in Russian).