Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia-Reference-Cited by-同舟云学术

Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia

Published:2023-01-19 Issue:4 Volume:21 Page:13-19
ISSN:1819-3684
Container-title:Bulletin of Siberian Medicine
language:
Short-container-title:Bûll. sib. med.

Author:

Bratishko K. A.¹^ORCID,Logvinova L. A.¹^ORCID,Ivanov V. V.¹^ORCID,Zhirkova A. M.²^ORCID,Ufandeew A. A.¹^ORCID,Buyko E. E.¹^ORCID,Zima A. P.¹^ORCID,Rabcevich E. S.³^ORCID,Kuznecova M. V.¹^ORCID,Belousov M. V.¹^ORCID,Perminova I. V.²^ORCID,Zykova M. V.¹^ORCID

Affiliation:

1. Siberian State Medical University

2. Lomonosov Moscow State University

3. Siberian State Medical University; National Research Tomsk State University

Abstract

Aim. To assess the effect of iron-rich humic substances on hematological parameters in acute post-hemorrhagic and iron deficiency anemia.Materials and methods. Materials for the study were samples of iron-rich active pharmaceutical ingredients based on humic substances (Fe(III) hydroxide complexes with humic substances and polymaltose): HA-Fe3+, HA-PMFe3+, FA-Fe3+, and FA-PM-Fe3+. The anti-anemic activity of the substances was studied on 53 female Wistar rats of the conventional rat line in the model of acute posthemorrhagic and iron deficiency anemia. Anti-anemic activity was assessed by the hemoglobin level, erythrocyte count, hematocrit, and serum iron level.Results. The studied substances HA-Fe3+ and FA-Fe3+ are the most effective in correcting the consequences of both experimental acute posthemorrhagic anemia and iron deficiency anemia. Their effect is comparable to that of the positive control drug Ferrum Lek.Conclusion. Fe(III) hydroxide complexes stabilized by humic and fulvic acids exhibit anti-anemic activity.

Publisher

Siberian State Medical University

Subject

Molecular Medicine

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