Challenges in the diagmosis of cervical pathologies-Reference-Cited by-同舟云学术

Challenges in the diagmosis of cervical pathologies

Published:2024-01-24 Issue:4 Volume:22 Page:201-209
ISSN:1819-3684
Container-title:Bulletin of Siberian Medicine
language:
Short-container-title:Bûll. sib. med.

Author:

Chernov D. Y.¹^ORCID,Tikhonovskaya O. A.¹^ORCID,Logvinov S. V.¹^ORCID,Petrov I. A.¹^ORCID,Yuriev Y. S.¹^ORCID,Zhdankina A. A.¹^ORCID,Gerasimov A. V.¹^ORCID,Zingalyuk I. V.¹^ORCID,Mikheenko G. A.¹^ORCID

Affiliation:

1. Siberian State Medical University

Abstract

This review deals with the current state of affairs in the diagnosis of cervical squamous intraepithelial lesions. Transformation of classifications of cervical pathologies is considered. The role of cytological (liquid-based and conventional cytology), molecular biological (Digene Hybrid Capture test), immunohistochemical (p16INK4α, Ki-67), and histologic methods in the diagnosis of cervical lesions is discussed. Particular attention is paid to the diagnosis of human papillomavirus infection. Performance indicators of screening programs based on primary determination of human papillomavirus (HPV) DNA in comparison with common cytological methods are presented. Tropism of HPV to various parts of the cervix, which predisposes to the formation of deep multifocal lesions, as well as the influence of the physical status of HPV on the treatment strategy and risks of relapse are considered.

Publisher

Siberian State Medical University

Reference57 articles.

1. Reagan J.W., Hamonic M.J. Dysplasia of the uterine cervix. Ann. N. Y. Acad. Sci. 1956;63(6):1236–1244. DOI: 10.1111/j.1749-6632.1956.tb32133.x.

2. Fu Y.S., Reagan J.W., Richart R.M. Definition of precursors. Gyn. Oncol. 1981;12(2 Pt 2):S220–231. DOI: 10.1016/0090-8258(81)90076-7.

3. Richart R.M. Cervical intraepithelial neoplasia. Pathol. Annu. 1973;8:301–328.

4. Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer. 2002;2(5):342–350. DOI: 10.1038/nrc798.

5. Solomon D., Davey D., Kurman R., Moriarty A., O’Connor D., Prey M. et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA. 2002;287(16):2114–2119. DOI: 10.1001/jama.287.16.2114.