Author:
Goremykin K. V.,Silkov A. N.,Shilov B. V.,Serebrov V. Yu.,Sazonov A. E.,Sennikov S. V.
Abstract
Alternatively spliced interleukins are very actively studied over the last years. Splice form of IL-4 — IL-4δ2 has antagonistic effects to its full form on proliferative activity of human mononuclear blood cells and their IL-6 production. Antagonistic effects between IL-4 and IL-4δ2 were confirmed and explained in this study due to combination of biochemical and computer methods.
Publisher
Siberian State Medical University
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