The role of μ-opioid receptors in the regulation of hepatic secretory function

Abstract

Influence of intraperitoneal and intracerebroventricular DAGO (μ-opioid agonist) on the bile secretion and composition was studied in white rats having intact and denervated liver. DAGO was demostrated to alter bile composition significantly both intraperitoneally and intracerebroventricularly and these effects were opposite. Intact liver innervation is a necessary condition for intracerebroventricular DAGO to have its effect on bile secretion.