Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Allodynia and Suppresses Spinal Substance P and Proinflammatory Cytokine Release in Rats-Reference-Cited by-同舟云学术

Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Allodynia and Suppresses Spinal Substance P and Proinflammatory Cytokine Release in Rats

Published:2015-01-01 Issue:1 Volume:95 Page:76-85
ISSN:0031-9023
Container-title:Physical Therapy
language:en
Short-container-title:

Author:

Chen Yu-Wen¹,Tzeng Jann-Inn²,Lin Min-Fei³,Hung Ching-Hsia⁴,Wang Jhi-Joung⁵

Affiliation:

1. Y-W. Chen, PhD, Department of Physical Therapy, China Medical University, Taichung, Taiwan, and Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.

2. J-I. Tzeng, MD, MS, Department of Food Sciences and Technology, Chia Nan University of Pharmacy and Science, Jen-Te, Tainan City, Taiwan, and Department of Anesthesiology, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan.

3. M-F. Lin, MS, Department of Physical Therapy, National Cheng Kung University, Tainan, Taiwan.

4. C-H. Hung, PhD, Department of Physical Therapy, National Cheng Kung University, No. 1 Ta-Hsueh Road, Tainan, Taiwan.

5. J-J. Wang, PhD, MD, Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.

Abstract

BackgroundTranscutaneous electrical nerve stimulation (TENS) is often used for management of chronic pain.ObjectiveThe purpose of this study was to investigate whether TENS altered postincisional allodynia, substance P, and proinflammatory cytokines in a rat model of skin-muscle incision and retraction (SMIR).DesignThis was an experimental study.MethodsHigh-frequency (100-Hz) TENS therapy began on postoperative day 3 and was administered for 20 minutes daily to SMIR-operated rats by self-adhesive electrodes delivered to skin innervated via the ipsilateral dorsal rami of lumbar spinal nerves L1–L6 for the next 27 days. The expressions of substance P, tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1beta (IL-1β) in the spinal cord and mechanical sensitivity to von Frey stimuli (4g and 10g) were evaluated.ResultsThe SMIR-operated rats displayed a marked hypersensitivity to von Frey stimuli on postoperative day 3. In contrast to the SMIR-operated rats, SMIR-operated rats after TENS administration showed a quick recovery of mechanical hypersensitivity. On postoperative days 3, 16, and 30, SMIR-operated rats exhibited an upregulation of substance P and cytokines (TNF-α, IL-6, and IL-1β) in the spinal cord, whereas SMIR-operated rats after TENS therapy inhibited that upregulation. By contrast, the placebo TENS following SMIR surgery did not alter mechanical hypersensitivity and the levels of spinal substance P, TNF-α, IL-6, and IL-1β.LimitationsThe experimental data are limited to animal models and cannot be generalized to postoperative pain in humans.ConclusionsThe results revealed that TENS attenuates prolonged postoperative allodynia following SMIR surgery. Increased levels of spinal substance P and proinflammatory cytokines, activated after SMIR surgery, are important in the processing of persistent postsurgical allodynia. The protective effect of TENS may be related to the suppression of spinal substance P and proinflammatory cytokines in SMIR-operated rats.

Publisher

Oxford University Press (OUP)

Subject

Physical Therapy, Sports Therapy and Rehabilitation

Link

http://academic.oup.com/ptj/article-pdf/95/1/76/31633609/ptj0076.pdf

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