Synthesis and Biological Evaluation of 3-Alkyl(Aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one Derivatives
Author:
Gürsoy Kol Özlem1ORCID, Aytemiz Fevzi2ORCID, Manap Sevda3ORCID, Yüksek Haydar3ORCID
Affiliation:
1. KARADENİZ TEKNİK ÜNİVERSİTESİ, FEN FAKÜLTESİ 2. KAFKAS ÜNİVERSİTESİ 3. KAFKAS ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ
Abstract
In the present study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3c, f, e) reacted with 4-methylthiobenzaldehyde to afford 3-alkyl(aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-ones (4c, f, e). The structures of three new compounds were established from the elemental analysis, IR, 1H NMR, and 13C NMR spectral data. The newly synthesized and recently synthesized 3-alkyl(aryl)-4-(4-methylthiobenzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one derivatives were analyzed using three methods for antioxidant activities. Compound 4a showed the best activity for the metal chelating effect. Furthermore, the compounds' antimicrobial activity was screened.
Funder
Scientific Research Projects Coordination Unit of Kafkas University
Publisher
Caucasian Journal of Science
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