The Relationship between Intestinal Flora and Sleep Disorders and Research Progress

Abstract

Insomnia is one of the most common sleep disorders, which is closely related to mood and stress. Long-term insomnia can not only lead to fatigue, poor concentration and other problems, but more serious cases can lead to memory loss, mood disorders and even neurodegenerative diseases. The current chemotherapeutics have many defects, such as high side effects and insufficient efficacy, so it is urgent to develop new prevention and treatment strategies. In recent years, with the deepening understanding of the ‘microbiome-gut-brain’ axis in the scientific community, gut microbes have been shown to regulate sleep function by communicating with the brain through several mechanisms: regulating the serotonin system; Regulating the blood-brain barrier; Produce functional metabolites. Breakthroughs have been made in theory to regulate the host’s biological rhythm and improve the nervous system problems caused by sleep disorders. It has great practical significance. Starting from the pathological mechanism of insomnia (including neurotransmitter system disorders and disorder of the Hypothalamic-Pituitary Aadrenal Axis (HPA) system), this paper will explain the pathogenesis of intestinal flora in sleep disorders and the interaction and internal relationship between the two.