Trend of incidence and mortality rate of other and ill-defined sites of lip, oral cavity and pharynx cancer in Central Serbia from 1999 to 2020

Abstract

Introduction: Cancer is causing death in countries with more or less economic development, and it is expected that the burden will grow worldwide, especially in countries with less developed populations, where about 82% of the global population lives. The aim of this study was to present and estimate trends in incidence, mortality rate and MIR of malignant neoplasm of otherand ill-defined sites of lip, oral cavity and pharynx cancer in Central Serbia from 1999 to 2020. Material and methods: The registry-based study was conducted using the data from the publically accessible Yearbooks of the Institute of Public Health of Serbia: Incidence and Mortality in Central Serbia, from 1999 to 2020. Joinpoint regression was used to determine the trend and annual percentage change (APC) of the incidence and mortality rate with corresponding 95% confidence intervals. Results: A total number of 558 cases (436men and 122women) of other and ill-defined lip, oral cavity and pharynx cancer sites registered in Central Serbia from 1999 to 2020. The crude rate (CR) and age-standardized rate (ASR-W) of incidence in males increased (p<0.001, for both) during the study period with APC of 4.8% and 9.0%, respectively. The crude rate (CR) and age-standardized rate (ASR-W) of mortality in males decreased (p<0.001, for both) during the study period with APC of -7.5%, and -7.2%, respectively. The mortality rate decrease was followed by the decline in MIR between 2001 and 2020 with anAPC of -5.6 (p<0.001). Conclusions: Our results reveal that the incidence of other and ill-defined lip, oral cavity and pharynx cancer sites in Central Serbia increased through the study period. The mortality rate and MIR for this cancer decreased during 22 years.