Author:
Đurić Milivoje,Makević-Đurić Mirjana,Pavlović Mirjana
Abstract
Adult-onset Still's disease is a rare autoimmune disorder accompanied by a triad of fever, exanthema, and arthralgia. In addition to this dominant presentation, it has a wide spectrum of clinical symptoms, with extensive involvement of multiple organs. Because of this, the diagnosis of adult-onset Still's disease remains one of exclusion and fulfilling sets of diagnostic criteria. We report on the case of a 20-year-old female who was initially treated for a suspected allergic reaction to a drug and then referred to an infectious disease specialist as fever of unknown origin accompanied with rash. This case highlights the challenges that clinicians face in differential diagnostic of Still's disease.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference10 articles.
1. Efthimiou P, Kontzias A, Hur P, Rodha K, Ramakrishna GS, Nakasato P. Adult-onset Still's disease in focus: Clinical manifestations, diagnosis, treatment, and unmet needs in the era of targeted therapies. Semin Arthritis Rheum 2021; 51: 858-74.;
2. Imboden JB, Hellmann DB, Stone JA. Current diagnosis and treatment in rheumatology. 4th ed. New York: McGraw-Hill Companies, 2020; 166-9.;
3. Ma Y, Meng J, Jia J, et al. Current and emerging biological therapy in adult-onset Still's disease. Rheumatology (Oxford) 2021; 60: 3986.;
4. Mehta B, Efthimiou P. Ferritin in adult-onset Still's disease: just a useful innocent bystander? Int J Inflam 2012; 2012: 298405.;
5. Gerfaud-Valentin M, Jamilloux Y, Iwaz J, Sève P. Adult-onset Still's disease. Autoimmun Rev 2014; 13: 708-22.;