Author:
Apostolović-Stojanović Milica,Radojković Milica,Stojanović Aleksandar,Vukomanović Vladan
Abstract
Introduction: Several classes of drugs can cause atrial fibrillation (AF) in patients without heart disease, as well as the occurrence of AF in pre-existing heart disease. Drug-induced AF is most often clinically manifested in the form of paroxysms. High doses of intravenous methylprednisolone (HDMP) in the treatment of chronic lymphocytic leukemia (CLL) have been associated with the occurrence of various adverse effects, including AF. The exact mechanism of HDMP-induced AF is unknown. Case presentation: We present the case of a patient with CLL in whom AF occurred after the administration of a high dose of intravenous methylprednisolone. Conclusion: Physicians should be aware of the special circumstances in the treatment of CLL, because drug-induced AF can be a side effect that limits further therapy.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference33 articles.
1. January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2019 Jul 9;74(1):104-132. doi: 10.1016/j.jacc.2019.01.011.;
2. Falk RH. Etiology and complications of atrial fibrillation: insights from pathology studies. Am J Cardiol. 1998 Oct 16;82(8A):10N-17N. doi: 10.1016/s0002-9149(98)00735-8.;
3. van der Hooft CS, Heeringa J, van Herpen G, Kors JA, Kingma JH, Stricker BH. Drug-induced atrial fibrillation. J Am Coll Cardiol. 2004 Dec 7;44(11):2117-24. doi: 10.1016/j.jacc.2004.08.053.;
4. Yang X, Li X, Yuan M, Tian C, Yang Y, Wang X, et al. Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms. Front Pharmacol. 2018 Oct 16;9:1058. doi: 10.3389/fphar.2018.01058.;
5. Aslam AK, Vasavada BC, Sacchi TJ, Khan IA. Atrial fibrillation associated with systemic lupus erythematosus and use of methylprednisolone. Am J Ther. 2001 Jul-Aug;8(4):303-5. doi: 10.1097/00045391-200107000-00013.;