Predictors of quality of life in patients with end-stage renal disease on hemodialysis and with Kidney Transplantation

Abstract

Introduction: The aim of the study was to investigate the impact of various factors on the quality of life (HRQoL) of patients with chronic kidney disease (CKD) treated with hemodialysis (HD) and kidney transplantation (KT) in the Specialized Center of the Military Medical Academy (VMA). Material and Methods: The study was designed as a cross-sectional study, and conducted on a sample of 144 subjects (67 HD and 77 KT) patients. We evaluated HRQOL using a 15D standardized questionnaire. The data were collected by anamnesis, physical examination, antrophometric measurement, analysis of medical records, analysis of conducted questionnaired and laboratory tests. Results: The study groups did not differ significantly in terms of gender, marital status and educational level, while a significant difference was observed with respect to age, working status, BMI, hemoglobin, albumin, urea, glucose and CRP concentrations. He results of the correlation analysis between the total 15D score of HRQoL and the examined parameters showed that age and unemployment were significantly negatively correlated with quality of life in both study groups (HD: p <0.001; KT p <0.005 for both correlations). A positive correlation of the total 15D score of HRQoL. Conclusion: The largest number of studies examining the quality of life of patients with terminal renal insufficiency are cross-sectional and there are significantly fewer prospective studies that would follow patients for shorter or longer periods and compare their HRQoL. The results of both studies indicate that the transplant is associated with a better quality of life compared to hemodialysis, which is consistent with our results.