Abstract
Introduction: Over the past few decades, proton pump inhibitors (PPIs) have been used more often; nonetheless, there are concern regarding misuse and the severe adverse effects that have been described. Methods: This paper will present information from relevant professional/scientific sources including Scopus, EBSCO, PubMed regarding unwanted adverse events of PPIs. Topic: The causality of correlations between PPI usage and possible adverse effects is unknown. Increased risk of kidney, liver, and cardiovascular disease; dementia; gastrointestinal tract enteroendocrine tumors; susceptibility to respiratory and gastrointestinal infections; and reduced nutritional absorption are just a few of the long-term adverse effects of widespread use of PPI that have come to light. Thus, given growing concerns regarding PPI overuse in the general population, the purpose of this investigation is to review the relationship between PPI usage and the risk of major side consequences. Conclusion: Due to the numerous known side effects of PPIs on the system, further study is necessary, including changing the drug's molecular structure and creating a new medication from its parent. By administering these drugs effectively for the relevant diagnosis, reevaluating patients' symptoms on a regular basis to determine the least amount and duration of therapy, and closely monitoring any potential side effects, it is feasible to minimize expenditures with health risk and maximize beneficial outcomes.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference44 articles.
1. Wilder-Smith, C.; Halter, F.; Ernst, T.; Gennoni, M.; Zeyen, B.; Varga, L.; Roehmel, J.J.; Merki, H.S. Loss of acid suppression during dosing with H2receptor antagonists. Aliment. Pharmacol. Ther. 1990, 4 (Suppl. 1), 15-27;
2. Cederberg, C.; Rohss, K.; Lundborg, P.; Olbe, L. Effect of once daily intravenous and oral omeprazole on 24-hour intragastric acidity in healthy subjects. Scand. J. Gastroenterol. 1993, 28, 179-184;
3. Chen, Y. et al. Will proton pump inhibitors increase the risk of diabetes mellitus? A systemic review and meta-analysis. Turk. J. Gastroenterol. 2022; 33, 497-504;
4. De laCobaOrtiz,C.; ArguellesArias, F.;Martin deArgila de Prados,C.; JudezGutierrez, J.; Linares Rodriguez,A.; Ortega Alonso, A.; Rodriguez de Santiago, E.; Rodriguez-Tellez,M.; VeraMendoza,M.I.; Aguilera Castro, L.; et al. Proton-pump inhibitors adverse effects: A review of the evidence and position statement by the Sociedad Espanola de Patologia Digestiva. Rev. Esp. Enferm. Dig. 2016, 108, 207-224;
5. Pottegard, A.; Broe, A.; Hallas, J.; de Muckadell, O.B.; Lassen, A.T.; Lodrup, A.B. Use of proton-pump inhibitors among adults: A Danish nationwide drug utilization study. Ther. Adv. Gastroenterol. 2016, 9, 671-678;