Abstract
Melatonin, an evolutionarily old molecule, is found in many living organisms. This neurohormone is known to control many physiological processes, including circadian rhythm, mood, and behavior. Melatonin was discovered to be a direct free radical scavenger. By activating its receptors, it stimulates a wide range of signaling pathways. It has been proven that melatonin exerts neuroprotective and antidepressant like effects. Also, many researchers have found that melatonin plays an important role in various cardiovascular diseases. In the near future, melatonin will be a promising agent to control the fate of mesenchymal stem cells by regulating the generation of reactive oxygen species and the release of immune factors in regenerative medicine. Collectively, the studies link melatonin to a variety of outcomes and have a strong regulatory impact on numerous physiological processes in the body.
Funder
Ministry of Education, Science and Technological Development of the Republic of Serbia
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference223 articles.
1. ACUÑA-CASTROVIEJO, D., NOGUIERA-NAVARRO, M. T., REITER, R. J., ESCAMES, G. (2018): Melatonin actions in the heart; more than a hormone. Melatonin Research 1 (1): 21-26. doi: 10.32794/mr11250002;
2. ABDULLAEV, S.A., GLUKHOV, S.I., GAZIEV, A.I. (2021): Radioprotective and radiomitigative effects of melatonin in tissues with different proliferative activity. Antioxidants 10 (12): 1885. doi: 10.3390/antiox10121885;
3. ADI, N., MASH, D. C., ALI, Y., SINGER, C., SHEHADEH, L., PAPAPETROPOULOS, S. (2010): Melatonin MT1 and MT2 receptor expression in Parkinson's disease. Medical Science Monitor 16 (2): Br61-67;
4. ALIZADEH, M., KARANDISH, M., ASGHARI JAFARABADI, M., HEIDARI, L., NIKBAKHT, R., BABAAHMADI REZAEI, H., MOUSAVI, R. (2021): Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Nutrition and Metabolism 18 (57): 1-11. doi: 10.1186/s12986-021-00586-9;
5. ALSTON, M., CAIN, S.W., RAJARATNAM, S.M.W. (2019): Advances of melatonin-based therapies in the treatment of disturbed sleep and mood. Handbook of Experimental Pharmacology 253: 305-319. doi: 10.1007/164_2018_139;