Correlation between oxidative stress parameters and left ventricular geometry in patients with chronic heart failure

Abstract

Oxidative stress, as one of the pathophysiological mechanisms involved in the reduction of myocardial contractility, stimulates the proliferation of cardiac fibroblasts and the activation of matrix metalloproteinases, which leads to extracellular matrix remodeling. Left ventricular hypertrophy (LVH) is a well-known independent risk factor for cardiovascular events. The aim of this research was to determine the connection between the parameters of oxidative stress and left ventricular geometry indicators in patients with chronic heart failure. The study included 81 subjects diagnosed with heart failure and 68 subjects in the control group. Parameters of myocardial morphology and left ventricular function were measured by echocardiography. Thiobarbituric acid reactive substances (TBARS) content, advanced oxidation protein products (AOPP), total serum SH groups and catalase activity were performed in both groups. The results showed that there were significantly higher concentrations of TBARS, AOPP, and SH groups in patients compared to controls (p < 0.01) and higher concentration of TBARS in patients with concentric hypertrophy compared to patients with normal geometry (p < 0.05). Correlation analysis showed a strong positive correlation between geometry parameters and myocardial function and TBARS and negative correlation between the right ventricule diameter and catalase activity. The results of this study show that oxidative stress parameters are significantly elevated in patients with heart failure, and that concentrations of TBARS and AOPP - the markers of lipid and protein oxidation, strongly correlate with left ventricular geometry parameters.