Abstract
Herpes simplex viruses (HSV) present one of the most frequent groups of viruses in the human population. Herpes simplex infections manifest through varying symptoms and lesions of the orofacial or genital tract. The peak of viral titers occurs within the first 24 h in both genital herpes and herpes labialis infections. Due to the rapid viral replication and subsequent progression of lesions in both Herpes labialis (HL) and Herpes genitalis (HG), the therapeutic window for treating HSV infections with antiviral drugs is narrow. It is important to recognize prodromal symptoms in patients and subsequently (self-)administer appropriate therapy. Clinical trials have shown that the shorter duration of higher doses of antiviral drugs, the more suitable and equally or even more effective results are obtained. According to the analysed literature, Acyclovir remains the most effective choice of treatment for the majority of patients. In some cases, other similar antiviral drugs could be effective when the treatment with Acyclovir fails to give the expected results.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference8 articles.
1. Zhu S, Viejo-Borbolla A. Pathogenesis and virulence of herpes simplex virus. Virulence. 2021 Dec;12(1):2670-702;
2. Zinser E, Krawczyk A, Mühl-Zürbes P, Aufderhorst U, Draßner C, Stich L, et al. A new promising candidate to overcome drug resistant herpes simplex virus infections. Antiviral Res. 2018 Jan;149:202-10;
3. Nikkels AF, Piérard GE. L'herpès labial récidivant. Comment traiter et prévenir au mieux [Recurrent labial herpes. How to treat and prevent it best]. Rev Med Liege. 2006 May-Jun;61(5-6):442-7;
4. Whitley R, Baines J. Clinical menagement of herpes simplex virus infection:past, present and future. F1000Res. 2018; 7:F1000 Faculty Rev-1726;
5. Medenica Lj. Herpes genitalis. U: Dermatovenerologija sa propedevtikom. Bosiljka M. Lalević, Ed. Beograd: Medicinski fakultet Univerziteta u Beogradu, CIBID, 2018. 340-2;