Relationship between serum thyroid hormone and interleukin-1b levels and postmortem tissue deiodinase activity in critically ill patients

Abstract

Background: This study investigated the relationship between serum thyroid hormones and interleukin-1b (IL-1b) levels and postmortem tissue deiodinase activity in critically ill patients. Methods: Serum thyroid hormones and IL-1b were measured on the 5th, 15th, and last day of 80 critically ill patients. Forty of these patients were non-survived, and liver and skeletal muscle were harvested to analyze type 1, 2, and 3 iodothyronine deiodinases (D1, D2, and D3) activity. Results: Serum thyroid stimulating hormone (TSH), tetraiodothyronine (T4), and triiodothyronine (T3) were decreased, and reverse triiodoth while serum TSH, T4, and T3 levels decreased or remained unchanged, and rT3 and IL-1b increase yronine (rT3) and IL-1b were increased in non-survivors. From day 5 to the last day, serum TSH, T4, and T3 levels increased, and rT3 and IL-1b levels decreased with time in survivors, while serum TSH, T4, and T3 levels decreased or remained unchanged, and rT3 and IL-1b increased in non-survivors. On the last day, liver D1 activity was negatively correlated with serum rT3 and IL-1b, while liver and skeletal muscle D3 activities were positively correlated. Conclusion: Serum thyroid hormones and IL-1b are correlated with postmortem deiodinase activity in critically ill patients.