Abstract
Background: Conclusions on susceptibility of MMP3-1612 5A/6A to morbid risk of coronary artery disease (CAD) are controversial. This meta-analysis aims to obtain the accurate relationship between them. Methods: Relevant literatures on susceptibility of MMP3-1612 5A/6A to morbid risk of CAD published before July 2019 were searched in PubMed, Web of Science, Cochrane Library, CNKI, VIP and Wanfang. Data were extracted from eligible literatures and analyzed by RevMan5.3 and STATA12.0 for calculating OR and corresponding 95% CI. Study selection: A total of 18 literatures reporting MMP3-1612 5A/6A and CAD were enrolled. Data extraction was conducted by two researches independently. Any disagreement was solved by the third research. Results: In recessive model (OR=1.3, 95% CI=1.2-1.64, P=0.03) and over-dominant model (OR=1.50, 95% CI=1.14-1.97, P=0.002), MMP3-1612 5A/6A was correlated to susceptibility of CAD. Subgroup analysis uncovered that in different genetic models, MMP3-1612 5A/6A was correlated to susceptibility of CAD in East Asian population (mainly Chinese population). Conclusion: MMP3-1612 5A/6A is closely linked to morbid risk of CAD. Gene-environment interaction is the research focus in future analyses.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Subject
Biochemistry (medical),Clinical Biochemistry
Reference34 articles.
1. Li GM, Zhang CL, Rui RP, Sun B, Guo W. Bioinformatics analysis of common differential genes of coronary artery disease and ischemic cardiomyopathy. Eur Rev Med Pharmaco 2018; 22(11): 3553-69;
2. Ershow AG, Brown LM, Cantor KP. Intake of tapwater and total water by pregnant and lactating women. Am J Public Health 1991; 81(3): 328-34;
3. Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Bi 2001; 17: 463-516;
4. Johnson JL, Jackson CL, Angelini GD, George SJ. Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques. Arterioscl Throm Vas 1998; 18(11): 1707-15;
5. Mittal B, Mishra A, Srivastava A, Kumar S, Garg N. Matrix metalloproteinases in coronary artery disease. Adv Clin Chem 2014; 64: 1-72;