D-glucurono-6,3-lactone as an interesting compound in the synthetic chemistry of carbohydrates related targets

Abstract

Isopropylidene acetals and ketals are frequent protecting groups in the chemistry of carbohydrates, particularly in organic synthesis. The yield of these derivatives must be high. Besides already published syntheses, we report a new way of synthesizing these derivatives in high yields and efficient deprotection. Acetyl and benzoyl groups are frequent protecting groups, and their use in carbohydrate chemistry , particularly on the derivative of D-glucurono-6,3-lactone was shown. Reactions of 1,2,5-triO-acetyl-D-glucurono-6,3-lactone with BF3 and (CH3CH2)3SiH, LiBH4, respectively and I2, were also reported.