Influence of cytostatics on relative gene expression in redox status, apoptosis and migration colorectal carcinoma model system-Reference-Cited by-同舟云学术

Influence of cytostatics on relative gene expression in redox status, apoptosis and migration colorectal carcinoma model system

Published:2023 Issue:45 Volume: Page:159-177
ISSN:1450-9636
Container-title:Kragujevac Journal of Science
language:en
Short-container-title:Kragujevac J Science

Author:

Pavić Jelena,Živanović Marko^ORCID,Virijević Katarina,Tanasković Irena^ORCID,Stanković Vesna^ORCID,Marić Nebojša^ORCID,Cvetković Danijela^ORCID,Filipović Nenad^ORCID

Abstract

Colorectal cancer is one of the leading causes of mortality worldwide. It is the most common malignancy and there is a need for new approaches in therapies. Surgery, radiation and chemotherapy are the key components of colon cancer treatment. Besides common chemotherapy, alternative therapies are being studied to increase treatment effectiveness and reduce side effects. In this article, colorectal carcinoma cells were treated with chemotherapeutics and relative gene expression was investigated for the genes coding cytoskeleton proteins: CDH1, CTNNB1 and CDH2; for redox status genes: GPX1, GPX2, GPX3, GPX4, TXNRD1, GSTP1, NFE2L2, NFKB1, HIF1A; and for apoptosis genes: CASP3, CASP8, CASP9, FAS, BCL-2 and BAX. The results of our research showed that some concentrations of chemotherapeutics increased the expression of certain genes. Molecular alterations that lead to colorectal cancer can determine appropriate and effective treatment - chemotherapeutics, as well as the design of direct therapeutic targets.

Funder

Ministry of Education, Science and Technological Development of the Republic of Serbia

Publisher

Centre for Evaluation in Education and Science (CEON/CEES)

Subject

General Medicine

Link

https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2023/1450-96362345159P.pdf

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