Abstract
Cholesterol participates in the construction of all body cells, steroid hormones, and bile acids. Its role in pregnancy is of key importance in the form of the synthesis of hormones without which conception and pregnancy would not be possible, and later in developing the physiological functions of the fetus as well. Triglycerides as the main energy substrate serve in the normal growth and development of the fetus. Normal reference values for lipid status in pregnancy have not been established yet. It has been proven that elevated, as well as reduced values of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) participate in pathological conditions of pregnancy - gestational diabetes mellitus, preeclampsia, macrosomia, restricted fetal growth, etc. The treatment of dyslipidemia is limited due to the lack of pharmacological studies on pregnant women, as well as the teratogenic effect of anti-lipid drugs. This review article deals with the effect of cholesterol and triglycerides on pregnancy, pregnancy outcomes, prenatal and postnatal effects on the fetus, as well as current and future treatment options.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference24 articles.
1. Lieberman M, Peet A. Marks' basic medical biochemistry: A clinical approach. 5th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2017;
2. Lehninger Principles of Biochemistry, Fourth Edition. David L. Nelson, Rabbi David Nelson, Ph.D., Michael M. Cox. PA: W.H. Freeman; 2004;
3. Gude NM, Roberts CT, Kalionis B, King RG. Growth and function of the normal human placenta.ThrombRes.2004;114(56):397407. doi:10.1016/j.thromres.2004.06.03. PMID: 15507270;
4. Ko CW, Qu J, Black DD, Tso P. Regulation of intestinal lipid metabolism: current concepts and relevance to disease. Nat Rev Gastroenterol Hepatol. 2020(3):169-183. doi: 10.1038/s41575-019-0250-7. PMID: 32015520;
5. Brizzi P, Tonolo G, Esposito F, Puddu L, Dessole S, Maioli M, et al. Lipoprotein metabolism during normal pregnancy. Am J Obstet Gynecol. 1999;181(2):430-4. doi: 10.1016/s0002-9378(99)70574-0;