A Review of Children’s Prosthetic Self-hygiene Using Antibacterial Silver Nanoparticles (AgNPs)

Abstract

Sports prostheses represent a critical facet in enhancing the mobility and quality of life for children with limb loss. However, prolonged usage of these prosthetic devices introduces substantial challenges related to hygiene and the heightened risk of infection. This comprehensive review endeavors to delve into the untapped potential of utilizing antibacterial silver nanoparticles (AgNPs) to foster self-hygiene practices in pediatric sports prostheses. AgNPs have emerged as a compelling area of research, largely attributable to their formidable antibacterial properties, offering revolutionary prospects in the realm of antibacterial therapy. Central to this exploration is an in-depth analysis of their antibacterial activity, elucidating their intricate mechanisms of action against bacterial agents. The unique physicochemical attributes, characterized by their diminutive size and expansive surface area, synergize to elevate their antibacterial efficacy significantly. The antibacterial mechanisms involve the controlled release of silver ions, which disrupt bacterial cell membranes, impede vital cellular processes, and provoke oxidative stress within the pathogens. Moreover, they exhibit the propensity for synergistic interactions when employed in tandem with conventional antibiotics, thereby positioning themselves as promising candidates for combination therapy. This review further encompasses a comprehensive survey of diverse methodologies employed for the synthesis of AgNPs and their multifarious application in various domains, including the realm of prosthetics and medicine. Nevertheless, as with any emerging technology, the implementation of AgNPs does not come without its challenges. Issues pertinent to the stability of AgNPs, potential toxicity concerns, and the development of bacterial resistance necessitate critical consideration for their successful integration into pediatric sports prostheses. In summation, AgNPs epitomize a compelling arsenal of antibacterial agents, propelling the possibilities of innovative therapeutic strategies in the battle against bacterial infections. This review underscores their remarkable potential while underscoring the imperative need for further research and development to unlock their full efficacy in the context of pediatric sports prostheses and beyond.