Infective endocarditis in patients with diabetes

Author:

Ponomareva E. Yu.1,Kunitsyna M. A.1

Affiliation:

1. Saratov State Medical University named after Razumovsky V.I., Department of Hospital Therapy of the Faculty of Medicine

Abstract

Diabetes mellitus (DM) is an adverse premorbid background for the development, course and outcome of infective endocarditis (IE), and therefore the combination of these diseases requires study. Objective: to study the clinical features and outcomes of infective endocarditis in patients with diabetes mellitus. Material and methods A retrospective (from 2001 to 2007) and a prospective (from 2008 to 2018) analysis of 347 patients with specifi c IE, 243 men and 104 women, aged from 17 to 83 (median age 44.8; 34–54). Results. 22 patients with IE, were diagnosed with diabetes, that is, the incidence of this pathology was 6.3%. Type 1 diabetes was observed in 7 (2% of the total number of patients and 32% among patients with a combination of IE and diabetes). Type 2 diabetes was diagnosed in 15 patients (4.3% and 68%, respectively). In subgroups of patients with IE and diabetes and without it, statistically signifi cant diff erences in age (p < 0.05), Charlson comorbidity index (p < 0.001), incidence of neurological complications ((p < 0.05), hospital mortality (p < 0.05) were noted, while patients with IE on the background of type 1 diabetes, had a more severe course of the disease. According to key characteristics of the pathological process in IE, localization, severity of systemic infl ammation, clinical and biochemical parameters, no signifi cant diff erences in the studied groups were found. Findings. The obtained results confi rm the literature data on fundamentally identical regularities of the course of IE in patients with and without diabetes. At the same time, the development of IE on the background of diabetes is a prognostically unfavorable combination of comorbid conditions, which requires special attention of physicians to such a contingent of patients, interaction of specialists for their successful management.

Publisher

Medical Informational Agency Publishers

Subject

General Medicine

Reference14 articles.

1. Habib G., Lancellotti P., Manuel J. et al. 2015 ESC Guidelines for the management of infective endocarditis. The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). European Heart Journal. Advance Access published August 29, 2015.

2. Tyurin V.P. Infectious endocarditis. M.: GEOTAR-media, 2013:368. (in Russian)

3. Dedov I.I., Shestakova M.V., Vikulova O.K. et al. Diabetes mellitus in the Russian Federation: prevalence, morbidity, mortality, parameters of carbohydrate metabolism and the structure of glucose-lowering therapy according to the fede ral register of diabetes mellitus, status 2017 g. Saharnyj diabet. 2018;21(3):144–159. (in Russian)

4. Pasechnik I.N., Ryabov A.L., Vershinina M.G. Sepsis and diabetes mellitus: state of the problem. Hirurgiya. 2016;1:80–84. (in Russian)

5. Kukushkin G.V., Starostina Е.G. Infections in patients with diabetes. RMZH. 2016;20:1327–1333. (in Russian)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3