Affiliation:
1. North-Western State Medical University named after I.I. Mechnikov of the Ministry of Health of Russia
Abstract
The review presents a modern understanding of the pathophysiology and mechanisms leading to thrombocytopenia, as well as emerging treatment methods for.
Publisher
Medical Informational Agency Publishers
Reference18 articles.
1. Boylan B., Hong C., Vipul R., Cathy P., Michael S., Kenneth D.F. et al. Anti-GPVI–associated ITP: An acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRγ-chain complex from the human platelet surface.Blood. 2004;104(5):1350– 1355. DOI: 10.1182/blood-2004-03-0896
2. Melikyan A.L., Pustovaya E.I., Tsvetaeva N.V., Ptushkin V.V., Gritsaev S.V., Golenkov A.K. et al. National clinical recommendations for diagnosis and therapy of idiopathic thrombocytopenic purpura (primary immune thrombocytopenia) in adults. Hematology and Transfusiology. Russian journal (Gematologiya i Trasfusiologia). 2017;60(1):44 –56. (in Russian).
3. Grodzielski M., Goette N.P., Glembotsky A.C., Pietto M.C.B., Méndez-Huergo S.P., Pierdominici M.S., et al. Multiple concomitant mechanisms contribute to low platelet count in patients with immune thrombocytopenia. Scientifi c Reports. 2019;9(1):2208. DOI:10.1038/s41598-018-38086-1
4. Matzdorff A., Meyer O., Ostermann H., Kiefel V., Eberl W., Kühne T. et al. Immune thrombocytopenia-current diagnostics and therapy: recommendations of a joint working group of DGHO, ÖGHO, SGH, GPOH, and DGTI. Oncology Research and Treatment. 2018;41(Suppl. 5):1 –30. DOI: 10.1159/000492187
5. Stasi R. Pathophysiology and therapeutic options in primary immune thrombocytopenia. Blood Transfusion. 211;9(3):262. DOI: 10.2450/2010.0080-10