Relationship of Neurospecific Serum Proteins with Clinical Features in Depressive Episode and Recurrent Depressive Disorder

Abstract

Background: depressive disorders remain an important medical problem and present significant economic and social burden on the health care system. This sets the task for the scientific community to increase the level of their detection, treatment and prevention. It seems promising to study the role of markers of neuronal disorders, in particular, proteins S-100, MBP, GFAP, in the pathogenesis of primary and recurrent depressive disorders.Purpose of the study: to determine the relationship between clinical and psychopathological characteristics of depressive disorders (anxiety, depression, aggressiveness) with markers of neuronal damage (S-100, MBP, GFAP) in primary Depressive Episode (DE) and Recurrent Depressive Disorder (RDR).Patients and methods: the study participants were 43 patients of the Mental Health Research Institute of the Tomsk National Research Medical Center Clinics with diagnoses DE (F32; n = 26) or RDR (F33; n = 17) according ICD-10. Clinical and psychopathological examination of patients with psychometric tools HDRS-17, HARS, BDHI and sampling of biological material for the study of blood serum biological markers were carried out upon admission before the start of active psychopharmacotherapy. Statistical analysis was performed using the IBM SPSS Statistics 25 program.Results: in the F32 group was found a correlation of all studied biomarkers with the severity of depressive symptoms and the hostility index according to the BDHI questionnaire (p < 0.05, Spearman).Conclusion: the relationship between markers of neuronal homeostasis disorders and various clinical and psychometric parameters is most pronounced in the case of primary Depressive Episode and is decreasing in the case of Recurrent Depressive Disorder. This may be important for the diagnostics and objectification of the severity, clinical dynamics in depressive disorders.