Clinical and Genetic Aspects of Depression Comorbid Coronary Heart Disease

Author:

Dolzhikov A. V.1ORCID,Troshina D. V.2ORCID,Golimbet V. E.1ORCID,Volel B. A.3ORCID

Affiliation:

1. Mental Health Research Centre

2. I.M. Sechenov First Moscow State Medical University Ministry of Health of Russian Federation (Sechenov University)

3. Mental Health Research Centre; I.M. Sechenov First Moscow State Medical University Ministry of Health of Russian Federation (Sechenov University)

Abstract

Objective: to analyze available scientific publications on the problem of clinical and genetic aspects of depressive disorders in patients with coronary heart disease (CHD). Material and methods: by keywords “coronary heart disease”, “mental disorders”, “depression”, “genetics”, “genetic markers”, “polymorphism”, “personality” articles in English and Russian were searched in the MEDLINE/PubMed, Scopus, Web of science, eLibrary databases in the period from 2020 to 2021. Conclusion: depression comorbid CHD is considered as a clinical problem due to its high prevalence, as well as its influence on the features of the course and prognosis of CHD, as well as on the compliance of patients. Heterogeneity of the clinical structure of depressive disorders in CHD (nosogenic, endogenomorphic, endogenous, somatogenic depression) causes difficulties in differential diagnosis and complex therapeutic measures. There are several factors contributing to the onset of depression in CHD patients: biological, clinical, personal characteristics. Genetic markers of depression in CHD, which have prognostic value, require further clarification.

Publisher

Medical Informational Agency Publishers

Subject

Biological Psychiatry,Psychiatry and Mental health,Clinical Psychology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Recent approaches to the diagnosis and therapy of monopolar depression;Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova;2023

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