Affiliation:
1. Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
2. Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; V.M. Bekhterev National Medical Research Center of Psychiatry and Neurology
Abstract
The aim of this review was to analyze domestic and foreign publications reflecting the main existing theories of tension-type headache (TTH) development and the search for common pathogenetic links of TTH with arterial hypertension (AH) as potential triggers for the development of the clinical TTH and AH phenotype.Methods. We searched for articles in databases (eLibrary.ru, Web of Science, Scopus, PubMed, Clinical Case) by keywords. Search depth – 2006–2021.Results. The analysis allowed us to identify the leading theories underlying the development of TTH: psychogenic, vascular, myofascial, biochemical and neurogenic. At the same time, a neurobiological theory has been considered: it combines some of the mechanisms of previously studied pathogenetic theories of TTH. In addition, there are the most important (from the clinical point of view) mechanisms of the comorbidity of TTH and AH, which underlie the development of the TTH + AH phenotype. In terms of these mechanisms, in recent years, it is of scientific interest to study the role of nitric oxide (NO) and NO-synthases, since they play an important role not only in the development of the comorbidity of two diseases simultaneously existing in one patient (phenotype «TTH and AH», but also in modulating the response to drugs for the treatment of TTH and AH. Modulators of NO and NO-synthases, which have been developed in recent years, can improve the efficacy and safety of therapy for this phenotype.Conclusion. New approaches to predicting and disease-modifying therapy of the TTH and AH phenotype can increase the efficiency and safety of treatment, and improve the quality of life of patients, and reduce the risk of cardiovascular complications.
Publisher
Medical Informational Agency Publishers
Subject
Psychiatry and Mental health,Neurology (clinical),Neurology
Reference86 articles.
1. Yakhno N.N., Parfenov V.A., Alekseev V.V. Headache. M.: Remedium, 2000:150 p. (In Russian)
2. Medvedeva L.A., Zagorulko O. I., Gnezdilov A.V. The prevalence of headache among patients of a specialized pain clinic. Russian Journal of Pain (Rossiiskyi zhurnal boli). 2013;1(38):25–26. (In Russian). https://elibrary.ru/item.asp?id=20284891& Accessed May 11, 2021.
3. Chowdhury D. Tension type headache. Annals of Indian Academy of Neurology. 2012;15(1):83–88. https://pubmed.ncbi.nlm.nih.gov/23024570/
4. Oganov R.G., Timofeeva T.N., Koltunov I.E., Konstantinov V.V., Balanova Yu.A., Kapustina A.V. et al. Arterial hypertension epidemiology in Russia; the results of 2003–2010 Federal monitoring. Cardiovascular therapy and prevention (Kardiovaskulyarnaya terapiya i profi laktika). 2011;10(1):9–13. (In Russian). https://cardiovascular.elpub.ru/jour/article/view/1436. Accessed May 10, 2021.
5. Rapsomaniki E., Timmis A., George J., Pujades-Rodriguez M., Shah A.D., Denaxas S. et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specifi c associations in 1·25 million people The Lancet. 2014;383(9932):1899–1911. https://doi.org/10.1016/S0140-6736(14)60685-1