Affiliation:
1. Clinical Institute of Pediatrics and Pediatric Surgery named after Academician Yu.E. Veltischev of the Russian National Research Medical University named after N.I. Pirogov
Abstract
Alternating hemiplegia (AH) is a rare and little researched disease. AH is characterized with early episodes of hemiplegia (from a few minutes to a few days), abnormal movements and cognition, and probable development of neurological defi ciency. Studies of genetic basis have led to discovery of mutations in gen ATP1A3, which codes alfa-3 subunit of Na+/K+-ATPase. For research, genetic data are considered most important prognostic information. Its diagnostics is diffi cult due to similarity of some symptoms to epilepsy and absence of deviations at neuro-visualisation. This article is an attempt to generalize world scientifi c experience and to determine most important research derections.
Publisher
Medical Informational Agency Publishers
Reference36 articles.
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