Affiliation:
1. Clinical Institute of Pediatrics and Pediatric Surgery named after Academician Yu.E. Veltischev of the Russian
National Research Medical University named after N.I. Pirogov
Abstract
Thе article describes two clinical cases of alternating hemiplegia (AH) in children of the same age group, but with different severity of clinical manifestations. The first patient, along with hemiplegic and epileptic seizures, demonstrates speech, behavioral and intellectual disorders, as well as motor disorders. The second patient, despite the presence of fairly frequent hemiplegic attacks, has no motor and intellectual disorders. The exact causes of such clinical variability are not yet known, which makes it difficult to predict the course in patients with AH.
Publisher
Medical Informational Agency Publishers
Reference19 articles.
1. Capuano A, Garone G, Tiralongo G, Graziola F. Alternating Hemiplegia of Childhood: Understanding the Genotype-Phenotype Relationship of ATP1A3 Variations. Appl Clin Genet. 2020;13:71–81. doi: 10.2147/TACG.S210325
2. Gergont A, Kaciński M. Alternating hemiplegia of childhood: new diagnostic options. Neurol Neurochir Pol. 2014;48(2):130–5. doi: 10.1016/j.pjnns.2013.05.003 Epub 2014 Feb 15. PMID: 24821639.
3. Verret S, Steele JC. Alternating hemiplegia in childhood: a report of eight patients with complicated migraine beginning in infancy. Pediatrics. 1971;47(4):675–80. PMID: 5089756.
4. Dittrich J, Havlovб M, Nevsнmalovб S. Paroxysmal hemipareses in childhood. Dev Med Child Neurol. 1979;21:800–7.
5. Aicardi J, Bourgeois, M, Goutieres, F. Alternating hemiplegia of childhood: clinical findings and diagnostic criteria. In: Andermann F, Aicardi J, Vigevano F, eds. Alternating Hemiplegia of Childhood. New York: Raven Press; 1995:3–18.