Blood indices reflecting infl ammatory changes in patients undergoing rehabilitation in the early recovery period of ischemic stroke

Abstract

   Background. Inflammatory changes in the vascular wall play an important role in the progression of cerebral atherosclerosis and the occurrence of its complications, including stroke. The infl uence of transcranial direct current stimulation and methods of secondary prevention of stroke on the inflammatory changes in the blood that develop in the acute period of acute cerebral catastrophe has not been fully studied.   Objective: to evaluate changes in blood parameters reflecting inflammatory changes in patients in the early recovery period of ischemic stroke against the background of complex rehabilitation measures, including transcranial direct current stimulation and secondary prevention measures.   Material and methods. 78 patients in the early recovery period of ischemic stroke aged from 42 to 75 years (average age 59.50 [54.50; 64.50]) were examined. Patients are divided into 2 groups: 1 — transcranial direct current stimulation was used (46 people, 59.0 %), 2 — it was not used (32 people, 41.0 %). In all patients, before starting the rehabilitation course and after its completion, the blood levels of C-reactive protein, fibrinogen, glycoprotein sCD40L, homocysteine and uric acid were determined.   Results. The level of C-reactive protein, fibrinogen and uric acid in patients during the rehabilitation course did not change signifi cantly, and the glycoprotein sCD40L exceeded the normative values before and after the course, decreasing during treatment in patients of group 1 (p = 0.027). The blood homocysteine concentration during the rehabilitation course was within the reference values, decreasing in patients of group 1 (p = 0.004). A statistical analysis revealed a dose-dependent relationship between taking atorvastatin and a decrease in the levels of uric acid, C-reactive protein and fibrinogen.   Conclusion. A course of rehabilitation using transcranial direct current stimulation in patients in the early recovery period of stroke is accompanied by a decrease in the level of glycoprotein sCD40L and blood homocysteine. Aggressive treatment with statins is accompanied by improvements in blood C-reactive protein, fibrinogen and uric acid levels.