Difficulties in diagnosing progressive supranuclear palsy

Author:

Topuzova M. P.1ORCID,Kipkeeva A. D.1ORCID,Panina E. B.1ORCID,Pavlova T. A.1ORCID,Popov K. D.1ORCID,Fedorov D. N.1ORCID,Smirnova A. Yu.1ORCID,Alekseeva T. M.1ORCID

Affiliation:

1. Federal State Budgetary Institution “Almazov National Medical Research Centre”

Abstract

Progressive supranuclear palsy is a sporadic neurodegenerative disease manifested by oculomotor disorders, akinetic- rigid syndrome, early development of postural instability, gradual development of frontal dementia, and pseudobulbar syndrome. Diagnosis of PNP is determined by the specifi c topical distribution of the degenerative lesion in the brain. This article describes a clinical case of a 67-year-old patient with PNP, a feature of which is the complexity of diff erential diagnosis, given the presence of a variety of comorbidities.

Publisher

Medical Informational Agency Publishers

Subject

Psychiatry and Mental health,Neurology (clinical),Neurology

Reference14 articles.

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3. Levin OS. Progressive Supranuclear Palsy (Steele–Richardson–Olszewski Syndrome). Extrapyramidal Disorders: The Guide to Diagnosis and Treatment: ed. V.N. Stok, I.A. Ivanova-Smolenskaya, O.S. Levin. Moscow: Medpress Inform, 2002:176–195. (In Russ.).

4. Bower JH, Maraganore DM, McDonnell SK, Rocca WA. Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Minnesota, 1976 to 1990. Neurology. 1997;49:1284–1288. https://doi.org/10.1212/wnl.49.5.1284

5. Levin OS, Amosova NA. Modern ideas about the mechanisms of neurodegeneration in progressive supranuclear palsy and multisystem atrophy. Neurological Journal (Nevrologicheskiy Zhurnal). 2003;4:50–57. (In Russ.).

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