Crystal Structure of (-)-7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid (Sitafloxacin) Sesquihydrate.
Author:
Affiliation:
1. Drug Metabolism and Analytical Chemistry Research Laboratory, Daiichi Pharmaceutical Co. Ltd.
2. Faculty of Pharmaceutical Sciences, Kyoto University
Publisher
Springer Science and Business Media LLC
Subject
Analytical Chemistry
Link
http://www.jstage.jst.go.jp/article/analsci/16/3/16_3_343/_pdf
Reference2 articles.
1. Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates
2. Crystal Structure of 7-((7S)-7-Amino-5-azaspiro(2.4)heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluoro-1-cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid.
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1. Crystal structure of [(2S)-1-[(3S)-3-carboxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl]-1-oxopropan-2-yl][(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]azanium chloride acetonitrile monosolvate;Acta Crystallographica Section E Structure Reports Online;2014-09-24
2. 7-[(7S)-7-Azaniumyl-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1S,2R)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylate methanol monosolvate;Acta Crystallographica Section E Structure Reports Online;2012-08-25
3. Characterization of Non-stoichiometric Hydration and the Dehydration Behavior of Sitafloxacin Hydrate;Chemical and Pharmaceutical Bulletin;2012
4. Studies on mechanism of thermal crystal transformation of sitafloxacin hydrates through melting and recrystallization, yielding different anhydrates depending on initial crystalline forms;International Journal of Pharmaceutics;2010-12-15
5. Synthesis, biodistribution and evaluation of 99mTc-sitafloxacin kit: a novel infection imaging agent;Journal of Radioanalytical and Nuclear Chemistry;2010-02-21
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