Synthesis, Spectral Characterization and Biological Evaluation of Platinum (II) Complexes of 1,3,4-oxadiazole-2-thione from Fatty Acids

Abstract

The fatty acid can be separated by separation techniques according to degree of unsaturated and chain length. In this paper fatty acid methyl esters are separated by Argentation Chromatography then converted to 1, 3, 4-oxadiazole. Platinum complexes of 1, 3, 4-oxadiazole are synthesized and Oxadiazole-2-thione ligands containing C=N and C=S groups as coordination sites may behave as a monobasic monodentate ligand. Antioxidant activity of complexes are measured by DPPH assay and in vitro cytotoxicity of the synthesized complexes measured against two human cancer cell line by MTT assay. In general, both MCF7 and A549 cell lines are sensitive to all the tested compounds. The Pt-complexes that contain unsaturated fatty acid are most active on the A549 cell line and important for human lung cancer, while the Pt4 has activity on MCF7 cell line and is important for human breast cancer.